A Proprietary Carnosine Booster Supporting Healthy Aging & Wellness
Innovation
A patent-pending formula that utilizes proprietary technology to increase beta-alanine bioavailability and absorption while effectively eliminating beta-alanine related paresthesia.
Clinical Trials
Results showed the elimination of paresthesia and an increased pharmacokinetic efficiency, confirming the enhanced delivery and bioavailability of TriBsyn™.
Scientifically Proven Claims
Improves muscle vitality and muscle working capacity. Supports cognitive performance and mental fatigue. Slows the process of age-related changes.
Formulation Flexibility
Increased efficiency allows efficacious dosing using significantly less beta-alanine, providing formulation flexibility for various delivery systems.
What Makes TriBsyn™ Unique?
Product Claims
Brain Health & Mood Improvement
Improves executive functioning, mental clarity and enhances cognitive processing. Supports brain health, cognitive function, and memory. Studies showed improved attention and task focus in adults. Promotes a healthy response to everyday stress. Fosters a more balanced mood and supports a sense of calm. Reduces mental fatigue.
Muscle & Bone Health
Increases muscle strength, working capacity and function in older adults. Increases carnosine levels in muscle, a powerful antioxidant that supports healthy aging throughout the body. Carnosine benefits bone and joint health through its anti-glycation action. Carnosine can contribute to overall skeletal integrity by directly protecting bone structure and supporting muscle function.
Healthy Immunity Support & Systemic Health
Provides multi-system support for the essential structure and function of healthy immunity. Carnosine helps the body’s cells fight oxidative damage. Carnosine chelates heavy metals. Supports healthy blood sugar levels already in the normal range.
Heart Health
Studies showed detoxification by protection from oxidative stress. Carnosine protects against lipid peroxidation in the body. Carnosine helps regulate muscle contractions. Carnosine supports healthy circulation.
TriBsyn™ Is:
Kosher, Halal, Vegan, Vegetarian, Gluten-free, No banned substances, Non-GMO, BSE/TSE free, Melamine-free, Non-irradiated, and Free of major allergens
Product Description:
Water soluble, Fine powder, Free flow, and Reduced clumping
Published Clinical Research Demonstrating TriBsyn™ Delivering Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination:
Study Highlights:
- TriBsyn™ is an encapsulated low-dose β-alanine complex.
- TriBsyn™ increased plasma β-alanine 4.5-fold compared to conventional β-alanine.
- TriBsyn™ achieved high plasma concentrations without the sensation of paresthesia.
Adequate availability of β-alanine is critical for maintaining health, protecting the body from toxins, and promoting longevity. High oral doses of β-alanine are often associated with uncomfortable symptoms of paresthesia, discouraging adherence to supplementation. This study aimed to evaluate the bioavailability, pharmacokinetics, and tolerability of a 400 mg Hydro Oleo encapsulated β-alanine complex (TriBsyn™) specifically designed to reduce paresthesia.
A randomized, double-blind, single-dose, three-treatment, three-way crossover oral bioavailability study was conducted in healthy older adults under fasting conditions. The study compared TriBsyn™ with low (400 mg) and high (1200 mg) doses of conventional β-alanine. TriBsyn™ (400 mg) achieved a nearly 4.5-fold and 1.3-fold increase in circulating concentrations compared to 400 mg and 1200 mg of conventional β-alanine, respectively.
Importantly, no adverse effects, including paresthesia, were observed despite the higher plasma concentrations. The Hydro Oleo technology facilitated the controlled release of β-alanine, ensuring enhanced bioavailability and tolerability. This innovative β-alanine complex demonstrates a safe, effective, and sensory-friendly approach to improving β-alanine absorption, particularly for older adults aiming to maintain good health.
The Science
What is TriBsyn™?
TriBsyn™ is a carnosine booster derived from CarnoSyn® beta-alanine and formulated with Hydro Oleo technology. This patent-pending formulation provides higher bioavailability and higher potency, enabling efficacious dosages at lower volumes while effectively eliminating paresthesia. TriBsyn™ is formulated to improve particle uniformity, flowability, stability, and reduce clumping.
Why TriBsyn™ is the Best Carnosine Booster?
As humans age, carnosine levels in both muscle and brain tissues decline progressively, leading to a cascade of physiological effects. This reduction in carnosine begins as early as the age of 30 and correlates with a decline in key life functions such as cognitive performance, muscle endurance, and the body’s ability to buffer lactic acid during physical exertion. Studies have demonstrated a 16% decrease in muscle carnosine levels between young adults (19-30 years) and middle-aged adults (31-50 years) (Everaert, 2011). In older adults (65-80 years), muscle carnosine levels drop by a striking 47%, contributing to a 7% reduction in muscle buffering capacity—a key factor in muscle performance (Tallon, 2007). These age-related declines can severely impact both physical and cognitive health.
Since beta-alanine is the rate-limiting factor in carnosine synthesis, our bodies demand more as we get older. Unfortunately, maintaining adequate carnosine levels can be challenging due to dietary restrictions (e.g., vegetarianism), aging, and stress (Johnson, 1992; Tallon, 2007; Everaert, 2011); and direct carnosine supplements suffer from the lack of efficiency, high cost per dose and unnecessary added ingredients.
This is where TriBsyn™ emerged as the clinically proven solution to boosting carnosine levels, delivering superior bioavailability, over four times the beta-alanine levels compared to conventional beta-alanine, and thus facilitating enhanced carnosine synthesis. Furthermore, TriBsyn™ exhibited a longer half-life compared to conventional beta-alanine, indicating a different release profile.
The Hydro Oleo Advantage
What sets TriBsyn™ apart from traditional beta-alanine formulations is its ability to maximize bioavailability while minimizing the unpleasant side effects often associated with beta-alanine, such as paresthesia—the tingling sensation caused by high oral doses. In a double-blind, randomized clinical study, TriBsyn™ not only improved bioavailability but also addressed the common challenge of paresthesia associated with conventional beta-alanine supplements.
Using metrics such as the Visual Analogue Score (VAS) and Qualitative Light Symptoms Inventory (QLSI), sensory side effects were assessed. No paresthesia or adverse effects were reported in the TriBsyn™ group, while the conventional beta-alanine groups exhibited increasing paresthesia with dose. TriBsyn™ (400 mg beta-alanine) recorded a VAS score of 0.62 (indicating almost absent symptoms), whereas conventional β-alanine (400 mg) and conventional β-alanine (1200 mg) scored 2.02 and 4.01 respectively. These results highlight the reduced sensory discomfort in the TriBsyn™ group, despite its higher bioavailability.
Bioavailability Matters: Greater Benefits for Mitochondrial, Muscle and Brain Health
The combination of intestinal lymphatic and portal vein absorption ensures that TriBsyn™ delivers significantly higher bioavailability than traditional beta-alanine supplements. This translates into greater levels of beta-alanine in the bloodstream, leading to more efficient production of carnosine in both muscle and brain tissues. As a result, users experience enhanced muscle endurance, improved physical performance, mitochondria protection from oxidative damage and carbonyl stress, and neuroprotection for brain health.
Dual Absorption Mechanisms: Intestinal Lymphatic System and Portal Vein
1. Absorption via the Intestinal Lymphatic System:
Hydro Oleo technology creates micelles—tiny lipid-based particles that encapsulate beta-alanine, making it easier for the compound to pass through the lipid-rich lymphatic system. This absorption pathway bypasses first-pass liver metabolism, which often reduces the bioavailability of many oral supplements. By entering systemic circulation directly through the lymphatic vessels, TriBsyn™ preserves a higher percentage of beta-alanine, ensuring sustained and elevated plasma levels.
2. Absorption via the Portal Vein:
A portion of TriBsyn™ beta-alanine is also absorbed through the portal vein, which transports it to the liver after initial absorption in the intestines. However, Hydro Oleo technology enables a greater proportion of beta-alanine to remain intact before it reaches the liver, minimizing its breakdown during the metabolic process and ensuring more beta-alanine enters systemic circulation.
This dual absorption strategy—combining lymphatic and gastrointestinal routes—leads to enhanced bioavailability and allows TriBsyn™ to deliver beta-alanine efficiently and consistently to muscles and the brain.
Overcoming Paresthesia: The SR CarnoSyn® Solution
The first major breakthrough was the development of SR CarnoSyn® sustained-release tablets. These tablets provided a solution to the paresthesia problem, delivering beta-alanine in a sustained-release format that eliminated paresthesia while maintaining efficacy. This innovation made it possible for individuals to enjoy the benefits of beta-alanine at the recommended efficacious dosage consistently, without the discomfort of paresthesia.
SR CarnoSyn® sustained-release tablets established the foundation for conducting placebo-controlled studies—a crucial step in validating the efficacy of beta-alanine through rigorous scientific research.
Researchers conducted an array of studies across various fields, from basic science to applied research, confirming the versatility of SR CarnoSyn®. These studies have shown that beta-alanine can be personalized for a wide range of users, demonstrating its potential far beyond traditional athletic performance and strength training.
Meeting the Challenge of Product Diversity
As the market evolved, so did consumer demand. While SR CarnoSyn® tablets were effective, the need for greater product variety and formulation flexibility became apparent. Consumers wanted more options in how they incorporated paresthesia-free beta-alanine into their daily routines.
This is where TriBsyn™ emerged as an innovative solution. With its patent-pending formula and Hydro-Oleo technology, TriBsyn™ offers a versatile powder that is clinically proven to boost the bioavailability of beta-alanine by more than 4 times. In the double-blind, three-way crossover clinical study, TriBsyn™ was shown to effectively eliminate paresthesia at the tested dosage while also requiring significantly less material to provide an efficacious dose.
The fine powder format of TriBsyn™ allows for further formulation flexibility, making it compliant for various product types. This evolution has provided a pathway for meeting the diverse needs of professional athletes and wellness enthusiasts as well as users of fortified and medical foods. Whether it is increasing carnosine levels, supporting muscle health and vitality, or enhancing cognitive function, TriBsyn™ is tailored to meet the evolving demands of today’s consumers.
TriBsyn™ Is Supported By Extensive Research
The extensive clinical and scientific research behind CarnoSyn® beta-alanine and TriBsyn™ provides a significant range of support for general wellness and healthy aging.
- Supports cognitive performance
- Enhances executive functioning and cognitive processing
- Improves muscle function and quality in older adults
- Improves muscle strength
- Increases carnosine levels
Carnosine Research
The Importance of Carnosine
Carnosine is a dipeptide composed of two key amino acids—L-histidine and beta-alanine—belonging to a family of histidyl dipeptides. As we age, carnosine levels in both muscle and brain tissues decline progressively, leading to a cascade of physiological effects. This reduction in carnosine begins as early as the age of 30 and correlates with a decline in key life functions such as cognitive performance, muscle endurance, and the body’s ability to buffer lactic acid during physical exertion. Beta-alanine supplementation has been widely used as a carnosine booster, as it is the rate-limiting factor in carnosine synthesis, according to scientific evidence. Due to its unique chemical properties, carnosine provides a variety of health benefits at efficacious dosages and has been clinically proven to improve brain and muscle health, among other health benefits.
The growing interest in carnosine’s fundamental properties and broad application potential is evident in the scientific community, with over 3,300 publications dedicated to carnosine research to date. Studies range from biochemistry and molecular biology to pharmacology and physiology. Carnosine’s application extends to a wide variety of fields, including neurology, sports sciences, and nutrition, with ongoing research highlighting its benefits in areas such as cognitive function, metabolic health, and more.
The vast scope of research on carnosine reflects its versatility, making it a valuable component in therapeutic strategies and dietary supplements aimed at improving human health and performance.
The Multifunctionality of Carnosine
As a multifunctional dipeptide, carnosine’s biochemical properties suggest it plays a critical role in several essential physiological processes, including acid–base balance, antioxidant defense, and the scavenging of lipid peroxidation products. These functions have generated substantial interest in carnosine’s potential as a therapeutic intervention for conditions related to oxidative stress and lipid peroxidation, such as cardiovascular disease, diabetes, and neurodegenerative disorders in academic research.
The interaction between muscle and cognitive function is a complex and fascinating aspect of health, with carnosine playing a pivotal role in this relationship. While the multiple benefits of carnosine may seem too good to be true, they are well-supported by clinical evidence and scientific research. Carnosine not only enhances mitochondrial energy production but also plays a critical role in detoxification processes within the body. By improving muscle performance and reducing fatigue, carnosine supports not only physical capacity but also cognitive resilience, demonstrating its multifaceted impact on overall health and well-being.
Additionally, carnosine serves as a natural antioxidant and heavy metal chelator. The chemical structure enables it to detoxify reactive carbonyl species (RCS) generated from lipid peroxidation and glycoxidation, inhibiting the formation of advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs) (Baye, 2017; Hipkiss, 2006). Consequently, carnosine protects against free radical-generated oxidative damage and AGE-induced cellular toxicity, counteracting numerous harmful biochemical processes associated with aging, stress, and various health conditions (Hipkiss, 2006; Ghodsi, 2018). It supports vital tissues, including the brain, eyes, musculoskeletal system, and cardiovascular system, and may enhance insulin sensitivity while preventing micro- and macrovascular complications. These effects may delay the onset of type 2 diabetes, cardiovascular diseases, and neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease (Caruso, 2023).
Major Health Benefits Associated With Using Carnosine Supplementation
Carnosine Supports Brain Health
Carnosine is a powerful antioxidant. Its strong anti-glycation ability protects the brain and has been shown to support cognitive function and mental acuity. Carnosine may also decrease occasional anxiety, support memory, delay mental fatigue, speed up executive function, and increase focus.
Carnosine Supports Muscle Vitality
Carnosine supports muscle mass and function which is vital to supporting our frame, aiding in balance, and maintaining strength for everyday activities and overall quality of life.
Carnosine Supports Heart Health
Carnosine helps to regulate muscle contractions and prevent lipid oxidation in the bloodstream. It also supports healthy circulation and contributes to maintaining already healthy blood pressure levels through vasodilation.
Carnosine Contributes To Overall Systemic Protection
Carnosine chelates heavy metals. It also supports blood sugar levels already in the healthy range. Carnosine regulates immune system response and acts as an anti-inflammatory factor. Its antioxidant properties also provide protection against damage caused by free radicals throughout the body.
Carnosine Supports Bone Health
Maintaining bone health is an important component of healthy aging, as bone fractures are directly linked to osteoporosis in older adults. Boosting carnosine levels can play a role here. Carnosine benefits bone and joint health through its anti-glycation action. Carnosine can also stimulate bone growth which contributes to overall skeletal integrity.
Frequently Asked Questions
TriBsyn™ is a patented carnosine booster providing beta-alanine with increased absorption and bioavailability. Beta-alanine, or 3-aminopropionic acid, is a naturally occurring beta amino acid. Inside the body, beta-alanine combines with existing histidine to create carnosine.
The health benefits of increased carnosine levels are well documented in thousands of scientific publications. There is extensive clinical research supporting carnosine’s impact on many of the body’s systems. It has been shown to support brain, muscle, heart, bone and overall systemic health. It is a powerful antioxidant that is naturally produced in the body but decreases as we age. Please ask our team for supporting study references.
Supplementing with carnosine is far less efficient and less cost-effective than supplementing with TriBsyn™. During digestion, absorption and transport, carnosine breaks down into beta-alanine and histidine before resynthesizing back into carnosine at the cellular level. TriBsyn™ is far more efficient, as the body avoids this extra step. Furthermore, carnosine formulations commonly contain only about 40% beta-alanine by weight which means the rest is unnecessary histidine and other ingredients, making them far less cost-effective.
TriBsyn™ is a proprietary carnosine booster with three important benefits confirmed by clinical research:
1. The TriBsyn™ proprietary and patent-pending formulation was shown to effectively eliminate paresthesia at the tested dosage.
2. TriBsyn™ delivers exceptional bioavailability generating over four times that of conventional beta-alanine.
3. TriBsyn’s™ increased efficiency improves formulation flexibility and allows for reduced ingredient inputs to achieve efficacious dosing.
A wide range of people can experience benefits from supplementing with TriBsyn™. As we age, our carnosine levels decrease, and the rate of decline accelerates over time. Declines can start as early as age thirty. TriBsyn™ is perfect for anyone looking to proactively support carnosine levels and fight age-related decline.
Maintaining adequate carnosine levels can be challenging due to dietary restrictions (e.g., vegetarianism), aging, and stress. A comparison of carnosine levels in the skeletal muscle of vegetarians and non-vegetarians found vegetarians had as much as 50% less carnosine due to their lack of dietary beta-alanine, found most abundantly in beef, pork, fish, and chicken.
TriBsyn™ is free of all major allergens. It is also gluten free, vegan friendly, non-GMO, kosher and halal certified. Onsite and third-party testing is done to help ensure safety, potency, and label claims.
Yes, TriBsyn™ is water soluble.
When stored in a tightly sealed container in a cool, dry location, TriBsyn™ has a three-year shelf life.
For general wellness and healthy aging, the recommended dosage is 386 mg of TriBsyn™ Powder (270 mg active beta-alanine) taken twice per day.
Please reach out to our sales team via the Contact Us form to learn more about price and/or to request a sample.